https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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‘Yes, that is certainly about appropriate. I look for a Bodily comprehension of biological units within a base-up way. I think you could distinguish 3 traces of investigate in my team at this time. The main worries chromosome composition: How can you have a metre-extensive DNA polymer folded and organised in such a microscopic cell? We have now made visualisation methods that let us to check how, for instance, SMC proteins loop DNA (movie on Youtube) so as to build up chromosomes.
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Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Considering the fact that 2000, Dekker has shifted the principle focus of his perform to biophysics exactly where he scientific tests the Homes of one biomolecules and cells utilizing the equipment of nanotechnology. This alteration of area was driven by his fascination for that remarkable working of biological molecular structures, in addition to with the extensive-term perspective that lots of attention-grabbing discoveries may be anticipated In this particular subject.[five] Present-day strains of study in his biophysics group are within the areas of:[6]
This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport as a result of a person one-walled carbon nanotube. Depending on small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigation lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes have been legitimate quantum wires with extremely very long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Microbiology has only been ceesdekker.net around to get a century, given that we started to examine micro-organisms extra very seriously. I assumed nanobiology was an correct time period, because all molecular biological relevant interactions take place at the nanoscale: a protein is a couple of nanometres in dimension, DNA is 2 nm thick.’
‘At the beginning we looked at biological programs which has a physical look at and acted on The premise from the equipment we realized. It took a number of years prior to we commenced Performing more on the big biological troubles. I then began to connect with it nanobiology, a term that did not exist at the time.
Dynamic ParB–DNA interactions initiate and preserve a partition condensate for bacterial chromosome segregation
‘Sure, I fully grasp individuals ended up surprised at enough time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it experienced turn into a bit bored, I didn’t understand much any more. The sphere went extra into the application aspect, how you could integrate nanotubes into Digital circuits.
But carbon nanotubes have remained a exploration matter of significant curiosity to lots of. In fact, the outlook on working with carbon nanotubes to develop realistic units, in areas for example radio-frequency electronics, electronic electronics and versatile electronics, stays brilliant.
Because 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Additional not too long ago his investigate has focused on researching chromatin construction and mobile division with germs on chip, though he can be attempting to eventually Develop artificial cells from The underside up.
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It had been an exceedingly fascinating time, through which I received plenty of guidance from Delft College of Technologies, the place I had been a professor at some time, and I started out many collaborations with molecular biologists. That served me learn a whole lot.’